Now, I would like to highlight another interesting study published by an Australian group. If you are following this blog, you probably have already read about the main FGFR3 activators, FGF9 and FGF18 (2,3). In the new article, this group describes the presence of FGF18 and FGFR3 in the human vertebra and their influence in bone growth.(4)
Relevance
Why is this relevant? Because it brings more evidence for the importance of FGF18 as a key player in cartilage development, a potential target for the treatment of achondroplasia.
Strategies to treat achondroplasia that instead of targeting FGFR3 aim their activators already exist, and one of them has received a lot of attention last year. I am referring to the strategy developed by the French group leaded by Dr. Elvire Gouze (5; reviewed here). In their study, they built a FGFR3-like molecule that is not fixed across the chondrocyte cell membrane like the natural receptor, so can circulate freely. They tested this compound in an animal model of achondroplasia and found that it was capable to rescue growth in the treated animals.
The proposed mechanism of action of this compound is that it would be capable of capture the FGFR3 activators before they could activate the cell membrane bound receptor. In simple words, the compound was trapping the TV signals before they could reach the house antenna, so the TV didn't show any program. Don't feel puzzled with this text. Take a look in the review published here. It could help you to better understand the story.
References
1. Krejci P. The paradox of FGFR3 signaling in skeletal dysplasia: why chondrocytes growth arrest while other cells over proliferate. Mut Res 2013; http://dx.doi.org/10.1016/j.mrrev.2013.11.001.
2. Garofalo S et al.Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice. J Bone Miner Res 1999; 14 (11): 1909-15. Free access.
3. Davidson D et al. Fibroblast growth factor (FGF) 18 signals through FGF Receptor 3 to promote chondrogenesis. J Biol Chem 2005; 280: 20509-15. Free access.
3. Davidson D et al. Fibroblast growth factor (FGF) 18 signals through FGF Receptor 3 to promote chondrogenesis. J Biol Chem 2005; 280: 20509-15. Free access.
4. Shu C et al. Comparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic and osteogenic development of the human foetal spine. J.Eur Spine J 2013; 22(8):1774-84.
5. Garcia S et al. Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice. Sci Transl Med 2013;5:203ra124.
